Lead Researcher OR Senior Researcher for Center for Advanced Genome Engineering

Company: St. Jude Children's Research Hospital
Location: Memphis
Posted on: April 2, 2026

Job Description:

This is an exciting opportunity for a Senior or Lead Researcher to join our Center for Advanced Genome Engineering (CAGE). The CAGE has three missions: Facilitate investigator-initiated genome editing projects using CRISPR-Cas9 Perform independent R&D to evaluate and develop new genome editing techniques Assist the gene and cell therapy programs at St. Jude Children’s Research Hospital. As a member of the Shondra Pruett-Miller laboratory, you will lead complex genome engineering projects, mentor junior staff, and collaborate with investigators across the institution to advance cutting-edge technologies. Responsibilities: Design and optimize genome editing strategies for custom cell lines Develop and troubleshoot CRISPR-based approaches Analyze and interpret experimental data; present findings at meetings Collaborate with investigators and guide project execution Mentor and train junior researchers Preferred Skills: Knowledge of molecular biology and genome editing Hands-on experience with CRISPR-Cas9 technology a plus Proficiency in cell culture and related techniques Ability to manage multiple projects and meet deadlines Excellent communication and leadership skills Experience with NGS analysis, flow cytometry, or automation is a plus Lead Researcher Minimum Education and/or Training: Bachelor’s degree in a relevant scientific area is required Minimum Experience: 5 years of research experience is required 3 years of experience is required with a Master’s degree No prior experience required with a PHD Strong knowledge and experience in understanding and application of underlying principles related to techniques being performed Experience in R&D methods and processes in lab setting, and execution of research projects for the laboratory preferred Proven performance in earlier role/comparable role Senior Researcher Minimum Education and/ or Training: Bachelor’s degree in relevant scientific area is required. Minimum Experience: Two (2) years of research experience is required. No prior experience is required with a Master’s degree. Working knowledge and understanding of the underlying concepts and principles of experimental design. Experience with the most widely used techniques used in the home laboratory. Proven performance in earlier role/comparable role. Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $60,320 - $105,040 per year for the role of Lead Researcher OR Senior Researcher for Center for Advanced Genome Engineering. Explore our exceptional benefits ! St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

Keywords: St. Jude Children's Research Hospital, Memphis , Lead Researcher OR Senior Researcher for Center for Advanced Genome Engineering, Engineering , Memphis, Tennessee