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Senior Research Technologist (Radiation Oncology)

Company: St. Jude Children's Research Hospital
Location: Memphis
Posted on: March 18, 2019

Job Description:

OverviewA unique research position is available immediately in the Departments of Radiation Oncology and Chemical Biology and Therapeutics to apply cell-based high-throughput and high-content screening methodologies and orthotopic xenograft tumor models to investigate molecular mechanisms of radiation response and evaluate small-molecule drug potentiation across and within diverse pediatric malignancies. This work will directly support a preclinical translational program dedicated to the enhancement of the therapeutic ratio of radiotherapy in pediatric cancers.

A collaboration has been established between the laboratory of Dr. Anang Shelat within the Department of Chemical Biology and Therapeutics and Dr. Christopher Tinkle within the Department of Radiation Oncology to develop an efficient preclinical program to identify radiation sensitizers and explore novel signaling pathways governing RT response. Resources include an impressive array of shared molecular biology, imaging and non-imaging based automated cellular screening and analytical equipment, as well as dedicated research space housing both orthovoltage and cesium irradiators and a recently installed Small Animal Radiation Research Platform (SARRP--). With the opening of the St. Jude Red Frog Events Proton Therapy Center, potential exists for preclinical proton radiotherapy.

The applicant must have a strong background in molecular biology and have experience with in vivo studies, including basic animal husbandry, tissue procurement and processing, and murine xenografting. The applicant must be comfortable working within the field of classic and more molecular-based radiobiology and be able to work with multivariate and complex biological and chemical datasets. The applicant is expected to work alongside basic biologists, clinicians, and pharmacologists in a project team environment, with the end goal of contributing to the discovery of small-molecules with potential to synergize with ionizing radiation relevant to the treatment of pediatric cancers.Minimum EducationBachelor's degree in an appropriate scientific field is requiredMinimum Experience




  • A minimum of three (3) years total work experience as a SJCRH Research Technologist or three (3) years relevant post-degree experience in a similar research environment is required with a Bachelor's degree.
  • A minimum of two (2) years total work experience as a SJCRH Research Technologist or two (2) years relevant post-degree experience in a similar research environment is required with a Master's degree.
  • No experience is required with a PhD in a related field.


    EEO StatementSt. Jude is an Equal Opportunity Employer

    No Search Firms:St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

    Keywords: St. Jude Children's Research Hospital, Memphis , Senior Research Technologist (Radiation Oncology), Healthcare , Memphis, Tennessee

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