SPR Scientist in Protein Technologies Center

Company: St. Jude Children's Research Hospital
Location: Memphis
Posted on: April 2, 2026

Job Description:

The Protein Technologies Center (PTC) comprises a team of 13 scientists within the Department of Structural Biology, specializing in protein biochemistry, molecular biology, biophysics, and structural biology. This center engages in collaborative efforts with various researchers at St. Jude to deepen the understanding of the molecular underpinnings of biological specificity and complexity. We are currently seeking an experienced Biophysicist/Surface Plasmon Resonance (SPR) Scientist to characterize molecular interactions utilizing SPR and other methodologies to support structural biology and ligand discovery initiatives. The World’s Brightest Minds Always Innovate At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities. State-of-the-art technologies. Extraordinary support. And a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. Quite simply, at St. Jude, we encourage you to dream big and stop at nothing when it comes to finding cures and saving children. This position is a hands-on laboratory role suitable for an individual who enjoys both the design and execution of assays, while closely collaborating with fellow scientists and investigators. The selected candidate will be responsible for the operation and maintenance of SPR instruments and must possess the capability to independently plan, optimize, and carry out experiments aimed at measuring kinetic and equilibrium binding constants. Additionally, the individual will explore, develop, and apply novel methods and technologies to advance the understanding of protein-ligand interactions, oligomerization, stoichiometry, and stability. Responsibilities: Independently design, execute, and analyze high- to medium-throughput biosensor-based molecular interaction assays utilizing SPR instruments. Oversee daily operations, maintenance, and scheduling for all biophysical instruments within the center. Engage in the preparation of manuscripts and the presentation of findings in various professional forums. Ideal Candidate: Proficient, hands-on experience with Biacore instruments (T200, S200, 8K, or 1K) and/or other systems such as Carterra LSA, Bruker, Nicoya, or Sartorius SF3 for analyzing diverse molecular interactions. A good understanding of macromolecular structure, protein-ligand interactions, and biophysical characteristics. A proven ability to manage multiple projects concurrently. Minimum Education and/or Training: Bachelor's degree in relevant scientific area is required. PhD strongly preferred. Minimum Experience: Eight (8) years of relevant work experience is required with a Bachelor's degree. Six (6) years of relevant work experience is required with a Master's degree. Three (3) years of relevant work experience is required with a PhD. Benefits Your health and well-being are important to us. That's why St. Jude Children's Research Hospital provides employees with high-quality benefits choices. We are committed to ensuring our benefits are competitive and affordable. St. Jude continues to cover medical premiums for employees and offers low additional costs for dependents. View all the benefits offered including Medical & Prescription Drug Plans, Dental Plan, Vision Plan, Financial Security, Retirement Plan, Living Well - Employee Wellness Program, Time Off Programs, Educational Benefits, Family Friendly Benefits, and Benefits Unique to St. Jude. Have More in Memphis Get the best of big-city amenities mixed with all the charm of a small-town feel when you live in Memphis. From our world-renowned music scene to our eclectic mix of food and people. Memphis is a place our employees are proud to call home. Our region enjoys a cost of living more than 20% lower than the national average and our state places no personal income tax on wages. Plus, Memphians spend five hours less per year in their daily commute compared to the national average. Learn how you can “ Have More in Memphis .” Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $86,320 - $154,960 per year for the role of SPR Scientist in Protein Technologies Center. Explore our exceptional benefits ! St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

Keywords: St. Jude Children's Research Hospital, Memphis , SPR Scientist in Protein Technologies Center, Science, Research & Development , Memphis, Tennessee